Program
The research unit combines molecular, cellular, and global genomic approaches to investigate epigenetic and epitranscriptomic modifications that occur in response to environmental or developmental signals and that are deregulated in tumour transformation.
The research unit combines molecular, cellular, and global genomic approaches to investigate epigenetic and epitranscriptomic modifications that occur in response to environmental or developmental signals and that are deregulated in tumour transformation. Several experimental tests have shown that the factors that bind DNA to specific sequences in collaboration with non-coding RNA and chromatin-modifying enzymes control epigenetic modifications. The study of the interaction between these components is necessary to understand the rules that govern gene expression and cell fate.
The work of the Unit is aimed at studying the mechanisms that determine these modifications and deciphering the mechanisms that that control cell fate. Projects in progress in the laboratory address the study of epigenetic modifications that determine stem cell differentiation, aging, and tumour transformation. These experiments allowed us to identify and characterize new molecular markers and cellular targets for anticancer therapies. (PI: S. Oliviero)
